 | BIOS (2020) |
| | You Are My Friend (2019) as Fred Rogers |
 | Toy Story 4 (2019) as Woody (voice) |
| | Greyhound (2019) |
| | The Ocean at the End of the Lane (2019) as The Man |
 | The Last Mile (2018) as Himself |
 | The Mayo Clinic, Faith, Hope and Science (2018) as Will Mayo |
 | Quincy (2018) as Himself |
 | The Post (2017) as Ben Bradlee |
 | The David S. Pumpkins Halloween Special (2017) as David S. Pumpkins |
 | Spielberg (2017) as Himself |
 | California Typewriter (2017) as Himself |
 | The Circle (2017) as Eamon Bailey |
 | Inferno (2016) as Robert Langdon |
 | Defying the Nazis: The Sharps' War (2016) as Waitstill Sharp (voice) |
 | Sully (2016) as Chesley 'Sully' Sullenberger |
 | A Hologram for the King (2016) as Alan Clay |
 | Mike Nichols: An American Master (2016) |
 | Toy Story at 20: To Infinity and Beyond (2015) as Himself |
 | Ithaca (2015) as Mr. Macauley |
 | Bridge of Spies (2015) as James B. Donovan |
 | Everything Is Copy (2015) |
 | Saturday Night Live 40th Anniversary Special (2015) as Himself |
 | Toy Story That Time Forgot (2014) as Woody (voice) |
 | The Concert for Valor (2014) as Himself |
 | All In (2014) as Himself |
 | And the Oscar Goes To... (2014) as Himself - Interviewee |
 | Saving Mr. Banks (2013) as Walt Disney |
 | Toy Story of Terror! (2013) as Woody |
 | Captain Phillips (2013) as Captain Richard Phillips |
 | Killing Lincoln (2013) as Himself - Narrator |
 | Inventing David Geffen (2012) as Himself |
 | Cloud Atlas (2012) as Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry |
 | Partysaurus Rex (2012) as Woody |
 | Electric City (2012) as Cleveland Carr |
 | Top Priority: The Terror Within (2012) as Himself - Academy Award Winning Actor (archive footage) |
 | Extremely Loud & Incredibly Close (2011) as Thomas Schell |
 | Le Voyage Extraordinaire (2011) as Himself (Archive Footage) |
 | Small Fry (2011) as Woody (voice) |
 | Boatlift (2011) as Narrator |
 | Larry Crowne (2011) as Larry Crowne |
 | Hawaiian Vacation (2011) as Woody (voice) |
 | Toy Story 3 (2010) as Woody (voice) |
 | Angels & Demons (2009) as Robert Langdon |
 | A Timeless Call (2008) as Himself - Narrator |
 | The Great Buck Howard (2008) as Mr. Gable |
 | Charlie Wilson's War (2007) as Charlie Wilson |
 | The Pixar Story (2007) as Himself |
 | The Simpsons Movie (2007) as Himself (voice) |
 | The True Story of Charlie Wilson's War (2007) |
 | Who Killed the Electric Car? (2006) as Himself |
 | Cars (2006) as Woody Car (voice) |
 | The Da Vinci Code (2006) as Robert Langdon |
 | Magnificent Desolation: Walking on the Moon (2005) as Narrator |
 | The Polar Express (2004) as Hero Boy / Father / Conductor / Hobo / Scrooge / Santa Claus (voice) |
 | Elvis Has Left the Building (2004) as Mailbox-Elvis |
 | The Terminal (2004) as Viktor Navorski |
 | The Ladykillers (2004) as Professor G.H. Dorr |
 | Rebels of Oakland: The A's, The Raiders, The '70s (2003) |
 | Horatio's Drive: America's First Road Trip (2003) as Horatio Nelson Jackson (voice) |
 | Catch Me If You Can: Behind the Camera (2003) as Himself |
 | Catch Me If You Can (2002) as Carl Hanratty |
 | Road to Perdition (2002) as Michael Sullivan |
 | The Rutles 2: Can't Buy Me Lunch (2002) |
 | America: A Tribute to Heroes (2001) |
 | Cast Away (2000) as Chuck Noland |
 | Shooting War (2000) as Narrator |
 | The Story Behind 'Toy Story' (2000) as Himself |
| | Walking the Mile (2000) as Himself |
 | The Green Mile (1999) as Paul Edgecomb |
 | Toy Story 2 (1999) as Woody (voice) |
 | Stephen King: Shining in the Dark (1999) as Himself |
 | Return with Honor (1999) as Narrator |
 | You've Got Mail (1998) as Joe Fox |
 | Saving Private Ryan (1998) as Captain John H. Miller |
 | The Harryhausen Chronicles (1998) as Himself (archive footage) |
 | That Thing You Do! (1996) as Mr. White |
 | The Universal Story (1996) as Himself (archive footage) |
 | The Celluloid Closet (1996) as Himself |
 | Lost Moon: The Triumph of Apollo 13 (1996) as Himself |
 | Toy Story (1995) as Woody (voice) |
 | Apollo 13 (1995) as Jim Lovell |
 | Through the Eyes of Forrest Gump (1994) as Himself |
 | Forrest Gump (1994) as Forrest Gump |
 | Philadelphia (1993) as Andrew Beckett |
 | Sleepless in Seattle (1993) as Sam Baldwin |
 | A League of Their Own (1992) as Jimmy Dugan |
 | Radio Flyer (1992) as Older Mike/Narrator (uncredited) |
 | The Bonfire of the Vanities (1990) as Sherman McCoy |
 | Joe Versus the Volcano (1990) as Joe Banks |
 | Saturday Night Live: 15th Anniversary (1989) as Himself |
 | Turner & Hooch (1989) as Scott Turner |
 | The 'Burbs (1989) as Ray Peterson |
 | Punchline (1988) as Steven Gold |
 | Big (1988) as Joshua "Josh" Baskin |
 | Dragnet (1987) as Pep Streebeck |
 | Every Time We Say Goodbye (1986) as David Bradley |
 | Nothing in Common (1986) as David Basner |
 | The Money Pit (1986) as Walter Fielding, Jr. |
 | Volunteers (1985) as Lawrence Whatley Bourne III |
 | The Man with One Red Shoe (1985) as Richard Harlan Drew |
 | Bachelor Party (1984) as Rick Gassko |
 | Splash (1984) as Allen Bauer |
 | Mazes and Monsters (1982) as Robbie Wheeling |
 | He Knows You're Alone (1980) as Elliot |
| | Sully: Sully Sullenberger - The Man Behind the Miracle as Himself |
