Trailer
Images
 | Kevin Hart as George Beard (voice) |
 | Ed Helms as Mr. Krupp / Captain Underpants (voice) |
 | Thomas Middleditch as Harold Hutchins (voice) |
 | Nick Kroll as Professor Poopypants (voice) |
 | Jordan Peele as Melvin (voice) |
 | Kristen Schaal as Edith (voice) |
 | Dee Dee Rescher as Ms. Ribble (voice) |
 | Brian Posehn as Mr. Rected (voice) |
 | Grey Griffin as Miss Anthrope (voice) |
 | Fred Tatasciore as Mr. Meaner (voice) |
 | Mel Rodriguez as Mr. Fyde (voice) |
 | David Soren as Tommy (voice) |
| Susan Fitzker as Mrs. Dayken (voice) |
| Lynnane Zager as Mrs. Beard (voice) |
| Tiffany Lauren Bennicke as Sad Girl (voice) |
| James Ryan as Mime (voice) |
 | Leslie David Baker as Officer McPiggly (voice) |
 | Sugar Lyn Beard as Goodie Two-Shoes Girl (voice) |
 | Lesley Nicol as Nobel Moderator (voice) |
 | Chris Miller as Nobel Audience Member (voice) |
| Coco Soren as Balloon Girl (voice) |
| Writing | |
| Nicholas Stoller | Writer |
Production | |
| Rob Letterman | Executive Producer |
Directing | |
| David Soren | Director |
Writing | |
| Dav Pilkey | Writer |
