Trailer
 | Brendan Fraser as Stu Miley |
 | Bridget Fonda as Dr. Julie McElroy |
 | John Turturro as Monkeybone (voice) |
 | Chris Kattan as Organ Donor Stu |
 | Giancarlo Esposito as Hypnos |
 | Rose McGowan as Miss Kitty |
 | Dave Foley as Herb |
 | Megan Mullally as Kimmy Miley |
 | Bob Odenkirk as Head Surgeon |
 | Whoopi Goldberg as Death |
| Pat Kilbane as Burger God Representative |
 | Lisa Zane as Medusa |
| Sandra Thigpen as Alice |
 | Wayne Wilderson as Hutch |
| Amy Higgins as Clarissa |
| Alan Gelfant as Dr. Edelstein |
| Kristin Norton as Nurse |
 | Chris Hogan as Bill, Bazoom Toy Representative |
 | Lucy Butler as Guest |
| John Sylvain as Ambulance Driver |
 | Lou Romano as Cop / Psycharist |
| Leon Laderach as Surgeon in Nightmare |
 | Scott Rogers as Surgeon |
| Cris Thomas-Palomino as Surgeon |
| Tony Panterra as Surgeon |
| Ted Rooney as Grim Reaper (voice) |
| Christopher Franciosa as Reaper Who Takes Lulu |
 | Mary Stein as Lulu |
| Fred Pierce as Reaper in Death's Office |
| Harper Roisman as Earl Biegler |
 | Kristopher Logan as Patron |
 | Scott Workman as Arnold the Super Reaper |
| Shawnee Free Jones as Lizzie Borden |
 | Ilia Volok as Rasputin |
| Edgar Allan Poe IV as Edgar Allan Poe |
 | Claudette Mink as Typhoid Mary |
 | Jon Bruno as Man in the Dungeon / Stephen King |
 | Owen Masterson as Jack the Ripper |
 | Jen Sung as Attila the Hun |
 | Tracy Zahoryin as Model |
| Sunshine Deia Tutt as Model |
| Jo Haugen Gash as Model |
| Lindsay Bryan as Model |
| Brooke Boisse as Model |
| Meron Abebe as Model |
| Mie Kringelbach as Model |
 | Rex Reddick as Museum Guard / Tuxedo Guard |
 | Sybil Azur as Museum Dancer |
 | Anne Fletcher as Museum Dancer |
 | Diane Mizota as Museum Dancer |
| Etty Lau as All-Girl Band Sax Player |
| LaTonya Holmes as All-Girl Band Percussionist |
| Lesli Jean Matta as All-Girl Band Drummer |
| Dawn Soler as All-Girl Band Member |
| Miko Watanbe as All-Girl Band Member |
| Frankie Pine as All-Girl Band Member |
| Anne King as All-Girl Band Member |
| Rachen Assapiomonwait as Korean Father |
| Veena Bidasha as Statue Woman |
| Michael Anthony Jackson as Bug Man |
 | Doug Jones as Yeti |
| Arturo Gil as Rat Guard |
| Jody St. Michael as Centaur |
 | Brian Steele as Jumbo the Elephant God |
| Leif Tilden as Cyclops |
| Tom Fisher as Community Service Cigarette Sweeper |
| Joseph S. Griffo as BBQ Pig |
| Kim Timbers-Patteri as Wasp Woman |
| Lisa Ebeyer as Betty the Bovine |
| Wayne Doba as Scorpion |
| Mark Viniello as Assbackward |
| Nathan Stein as Sea Monster |
| Ed Holmes as Buffalo Kuchina |
| Erica Gudis as Party Babe Hybrid #1 |
| Melinda Milton as Party Babe Hybrid #2 |
| Caroline A. Rice as Party Babe Hybrid #3 |
 | Joe Ranft as Streetsquash Rabbit (voice) |
 | Bruce Lanoil as Streetsquash Raccoon (voice) |
| Debi Durst as Streetsquash Snake (voice) |
| Phil Brotherton as Subramansa (voice) |
 | Roger L. Jackson as Arnold the Super Reaper (voice) |
| Jym Dingler as Community Service Cigarette Sweeper (voice) |
| Leslie Hedger as Assbackward (voice) |
| Toby Gleason as Buffalo Kachina (voice) |
| Allan Trautman as BBQ Pig (voice) |
| Mike Mitchell as Miss Hudiapp (voice) |
| Randall Bosley as Fred |
| Brendan Burns as Detective #1 |
| Robert "Duckie" Carpenter as Record Store Owner / Coma Victim |
 | Thomas Haden Church as Death's Assistant |
| Jamie Donovan as Reporter #1 |
| Roger Ferreira as Visitor |
| Wendy Fowler as Beautiful Fan |
| Paul Guiles as Reporter #2 |
| Harry Jay Knowles as Lucky |
| Jason Kravits as Guest |
| Skyler Marshall as Janitor |
| George Meyers as Bazoom Toy Rep |
| Michelle Shaffer as Woman with Bat |
| Tom Tangen as Burger God Representative |
| Sound | |
| Anne Dudley | Original Music Composer |
Editing | |
| Mark Warner | Editor |
Production | |
| Sam Hamm | Executive Producer |
Writing | |
| Sam Hamm | Writer |
Sound | |
| Steve Boeddeker | Sound Designer |
Camera | |
| Andrew Dunn | Director of Photography |
Production | |
| Chris Columbus | Executive Producer |
| Mark Radcliffe | Producer |
Editing | |
| Jon Poll | Editor |
Production | |
| Paula DuPré Pesmen | Associate Producer |
| Lata Ryan | Executive Producer |
| Michael Barnathan | Producer |
Editing | |
| Nicholas C. Smith | Editor |
Directing | |
| Henry Selick | Director |
Production | |
| Henry Selick | Executive Producer |
Visual Effects | |
| Anthony Scott | Animation |
| Webster Colcord | Animation |
| Jeff Newitt | Animation |
| Timothy Hittle | Animation |
Sound | |
| Lora Hirschberg | Sound Re-Recording Mixer |
Visual Effects | |
| Justin Kohn | Animation |
Sound | |
| Michael Semanick | Sound Re-Recording Mixer |
Visual Effects | |
| Phil Dale | Animation |
| Trey Thomas | Animation |
Art | |
| Mike Cachuela | Conceptual Design |
Writing | |
| Mike Cachuela | Storyboard |
Visual Effects | |
| Martin Meunier | Modeling |
| Brian Ormiston | Animation |
| Kevin MacLean | Animation |
| Paul Berry | Animation Supervisor |
| Owen Klatte | Animation |
| Josephine Huang | Animation |
Art | |
| Damon Bard | Art Department Manager |
Visual Effects | |
| Gisela Hermeling | Animation Manager |
